Identifying genes for diabetic nephropathy--current difficulties and future directions.

10-kDa proguanylin as a major guanylin molecule in human intestine and plasma and its increase in renal insufficiency. Biochem Biophys Res Commun 1994; 205: 1966–1975 34. Kinoshita H, Fujimoto S, Fukae H et al. Plasma and urine levels of uroguanylin a new peptide in nephrotic syndrome. Nephron 1999; 81: 160–164 35. Fukae H, Kinoshita H, Fujimoto S, Nakazato M, Eto T. Plasma concentration of uroguanylin in patients on maintenance dialysis therapy. Nephron 2000; 84: 206–210 36. Kikuchi M, Fujimoto S, Fukae H et al. Role of uroguanylin, a peptide with natriuretic activity, in rats with experimental nephrotic syndrome. J Am Soc Nephrol 2005; 16: 392–397